Invention Grant
- Patent Title: Mouse with deficiency of glutamate transporter GLAST function
- Patent Title (中): 谷氨酸转运蛋白GLAST功能缺乏的小鼠
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Application No.: US10553051Application Date: 2004-04-13
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Publication No.: US07642399B2Publication Date: 2010-01-05
- Inventor: Kohichi Tanaka , Takayuki Harada
- Applicant: Kohichi Tanaka , Takayuki Harada
- Applicant Address: JP Saitama
- Assignee: Japan Science and Technology Agency
- Current Assignee: Japan Science and Technology Agency
- Current Assignee Address: JP Saitama
- Agency: Foley & Lardner LLP
- Priority: JP2003-114793 20030418
- International Application: PCT/JP2004/005253 WO 20040413
- International Announcement: WO2004/092371 WO 20041028
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C12N15/00 ; C12N5/00
Abstract:
The present invention provides a GLAST knockout mouse lacking the function of an endogenous glutamate transporter GLAST gene, which shows: 1) an intraocular pressure within the normal range; and 2) a reduction in the number of cells in the retinal ganglions when compared with a wild-type normal mouse. Owing to the ocular properties, this knockout mouse is useful as a model for normal tension glaucoma. By using this knockout mouse, a compound useful for the treatment of normal tension glaucoma can be screened.
Public/Granted literature
- US20070011758A1 Mouse with deficiency of glutamate transporter glast function Public/Granted day:2007-01-11
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