An implementation of a technology, described herein, for facilitating the protection of computer-executable instructions, such as software. At least one implementation, described herein, may generate integrity signatures of one or more program modules—which are sets of computer-executable instructions—based upon a trace of activity during execution of such modules and/or near-replicas of such modules. With at least one implementation, described herein, the execution context of an execution instance of a program module is considered when generating the integrity signatures. With at least one implementation, described herein, a determination may be made about whether a module is unaltered by comparing integrity signatures. This abstract itself is not intended to limit the scope of this patent. The scope of the present invention is pointed out in the appending claims.