Invention Grant
- Patent Title: Diagnosis of sepsis or SIRS using biomarker profiles
- Patent Title (中): 使用生物标志物图谱诊断败血症或SIRS
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Application No.: US10704666Application Date: 2003-11-12
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Publication No.: US07645573B2Publication Date: 2010-01-12
- Inventor: Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Nicholas Bachur, Jr. , Robert W. Rosenstein , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
- Applicant: Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Nicholas Bachur, Jr. , Robert W. Rosenstein , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
- Applicant Address: US NJ Franklin Lakes
- Assignee: Becton, Dickinson and Company
- Current Assignee: Becton, Dickinson and Company
- Current Assignee Address: US NJ Franklin Lakes
- Agency: Jones Day
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34

Abstract:
The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished using a molecular diagnostics approach, involving comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.
Public/Granted literature
- US20040106142A1 Diagnosis of sepsis or SIRS using biomarker profiles Public/Granted day:2004-06-03
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