Invention Grant
- Patent Title: Cells having cardiac glycoside resistance
- Patent Title (中): 具有强心苷抗性的细胞
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Application No.: US10545491Application Date: 2004-02-13
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Publication No.: US07645603B2Publication Date: 2010-01-12
- Inventor: Alexandra Treschow , Sirac Dilber , Alar Aints
- Applicant: Alexandra Treschow , Sirac Dilber , Alar Aints
- Applicant Address: SE Huddinge
- Assignee: Avaris AB
- Current Assignee: Avaris AB
- Current Assignee Address: SE Huddinge
- Agency: Morrison & Foerster LLP
- Priority: SE0300412 20030214
- International Application: PCT/SE2004/000197 WO 20040213
- International Announcement: WO2004/072278 WO 20040826
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C12N9/00 ; C12N1/20 ; C12N15/00 ; C07H21/04

Abstract:
An isolated cell having a nucleic acid construct encoding a recombinant Na+, K+-ATPase α1-subunit protein resistant to cardiac glycosides, e.g., ouabain, is disclosed. Selected amino acid substitutions in the normal human Na+, K+-ATPase α1-subunit confers resistance to cardiac glycosides. Cardiac glycoside resistant Na+, K+-ATPase α1-subunits may be useful as selection markers in gene therapy and research applications.
Public/Granted literature
- US20060228343A1 Cardiac glycoside resistant non-immunogenic selection marker Public/Granted day:2006-10-12
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