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US07645603B2 Cells having cardiac glycoside resistance 失效
具有强心苷抗性的细胞

Cells having cardiac glycoside resistance
Abstract:
An isolated cell having a nucleic acid construct encoding a recombinant Na+, K+-ATPase α1-subunit protein resistant to cardiac glycosides, e.g., ouabain, is disclosed. Selected amino acid substitutions in the normal human Na+, K+-ATPase α1-subunit confers resistance to cardiac glycosides. Cardiac glycoside resistant Na+, K+-ATPase α1-subunits may be useful as selection markers in gene therapy and research applications.
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