Invention Grant
- Patent Title: Mass spectrometry techniques for determining the status of sepsis in an individual
- Patent Title (中): 用于确定个体败血症状态的质谱技术
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Application No.: US11647688Application Date: 2006-12-28
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Publication No.: US07645613B2Publication Date: 2010-01-12
- Inventor: Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Gary Siuzdak , Elizabeth J. Want , Zhouxin Shen , Nicholas Bachur, Jr. , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
- Applicant: Richard M. Ivey , Thomas M. Gentle, Jr. , Richard L. Moore , Michael L. Towns , Gary Siuzdak , Elizabeth J. Want , Zhouxin Shen , Nicholas Bachur, Jr. , Robert W. Rosenstein , James G. Nadeau , Paul E. Goldenbaum , Song Shi , Donald Copertino , James Garrett , Gregory Tice
- Applicant Address: US NJ Franklin Lakes
- Assignee: Becton, Dickinson and Company
- Current Assignee: Becton, Dickinson and Company
- Current Assignee Address: US NJ Franklin Lakes
- Agency: Jones Day
- Main IPC: G01N24/00
- IPC: G01N24/00

Abstract:
Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.
Public/Granted literature
- US20070184512A1 Mass spectrometry techniques for determining the status of sepsis in an individual Public/Granted day:2007-08-09
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