Invention Grant
US07645757B2 Derivatives of heteroaryl-alkylcarbamates, methods for their preparation and use thereof as fatty acid amido hydrolase enzyme inhibitors
失效
杂芳基 - 烷基氨基甲酸酯的衍生物，其制备方法和用作脂肪酸酰氨基水解酶抑制剂
- Patent Title: Derivatives of heteroaryl-alkylcarbamates, methods for their preparation and use thereof as fatty acid amido hydrolase enzyme inhibitors
- Patent Title (中): 杂芳基 - 烷基氨基甲酸酯的衍生物，其制备方法和用作脂肪酸酰氨基水解酶抑制剂
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Application No.: US11464355Application Date: 2006-08-14
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Publication No.: US07645757B2Publication Date: 2010-01-12
- Inventor: Ahmed Abouabdellah , Regine Bartsch-Li , Christian Hoornaert , Antoine Ravet
- Applicant: Ahmed Abouabdellah , Regine Bartsch-Li , Christian Hoornaert , Antoine Ravet
- Applicant Address: FR Paris
- Assignee: sanofi-aventis
- Current Assignee: sanofi-aventis
- Current Assignee Address: FR Paris
- Agent Balaram Gupta
- Priority: FR0401949 20040226
- Main IPC: A61K31/501
- IPC: A61K31/501 ; A61K31/541 ; A61K31/5355 ; A61K31/55 ; C07D417/04 ; C07D401/04 ; C07D403/04 ; C07D405/04 ; C07D409/04 ; C07D413/04 ; A61P29/00 ; A61P9/00 ; A61P3/00
Abstract:
The present invention is directed to compounds and compositions for the treatment of neurological diseases that cause neurogenic and neuropathic pain, inflammatory diseases, renal ishaemia, cardiovascular disease and other pathologies caused by the presence of endogenous cannabinoids and or other substrates resulting from the metabolic activities of fatty acid amido hydrolase (FAAH). These compounds are represented by the formula alkylene group; a salt thereof, or a hydrate or a solvate of said compound or said salt; where the variables are as defined in the attached specification.
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