Invention Grant
- Patent Title: Hydroisoindoline tachykinin receptor antagonists
- Patent Title (中): 羟基异吲哚啉速激肽受体拮抗剂
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Application No.: US10586727Application Date: 2005-01-26
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Publication No.: US07645790B2Publication Date: 2010-01-12
- Inventor: Jaime Lynn Bunda , Robert J. DeVita , Jinlong Jiang , Sander G. Mills
- Applicant: Jaime Lynn Bunda , Robert J. DeVita , Jinlong Jiang , Sander G. Mills
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent William Krovatin; Raynard Yuro
- International Application: PCT/US2005/002149 WO 20050126
- International Announcement: WO2005/073191 WO 20050811
- Main IPC: A61K31/4035
- IPC: A61K31/4035 ; C07D209/44
Abstract:
The present invention is directed to certain hydroisoindoline compounds of formula I which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
Public/Granted literature
- US20080280966A1 Hydroisoindoline Tachykinin Receptor Antagonists Public/Granted day:2008-11-13
Information query
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