Provided are a solid state image sensing device and method for sub-sampling using inter-column analog domain signal summation, where, in the solid state image sensing device, a CDS unit receives reset signals from neighboring columns of the same color in an APS array, receives video signals from pixels generating the reset signals, and generates modulation signals respectively corresponding to the differences between the reset signals and the video signals, the modulation signals are activated according to activation of the previous modulation signals, and a digital signal output circuit generates a corresponding digital signal based on the final modulation signal corresponding to the sum of inter-column analog video signals among the modulation signals.