Advertisers are permitted to put targeted ads on, or to serve ads in association with, various content such as search results pages, Web pages, e-mail, etc., without requiring the advertiser to enter and/or maintain certain targeting information, such as keyword targeting. This may be accomplished by using a searchable data structure, such as an inverted index for example, of available advertiser Web information. The advertiser Web information may include terms and/or phrase extracted from the advertiser's Website. In particular, a search query may be used to search for matching advertisers, and therefore matching ads. For example, the search query can be used to search an inverted index including words and/or phrases extracted from advertiser Websites. The advertiser Web page, or some other identifier, can be used as a key to search for an associated ad.