A method of producing a particle-dispersed liquid, using a channel of micro width having a core flow channel, includes: sending the particle-dispersed liquid containing larger particles to an inner portion of the core flow channel; separating and removing the larger particles from the particle-dispersed liquid; and sending the removed larger particles to an outermost part of the core flow channel. An outer diameter of the core flow channel is 50 to 5,000 μm.