A system for collecting, transporting and preparing a fecal specimen for examination includes a container, a closure selectively secured over an open end of the container, and a sample collection member coupled to the closure and extending into the container when the closure is secured thereto. In one embodiment, the closure includes a base and a cap that are hingedly coupled together. The cap is selectively moveable between a closed position that seals an aperture in the base, and an open position wherein the aperture is exposed to permit expelling contents of the container through the aperture. In another embodiment, the closure comprises a base having a spout and an aperture, and a cap coupled to the base for axial movement along the spout between open and closed positions. The system may further include a deodorant to mask or absorb odors.