Invention Grant
US07648827B2 Use of eukaryotic genes affecting cell cycle control or cell cycle progression for diagnosis and treatment of proliferative diseases
失效
使用影响细胞周期控制或细胞周期进程的真核基因来诊断和治疗增殖性疾病
- Patent Title: Use of eukaryotic genes affecting cell cycle control or cell cycle progression for diagnosis and treatment of proliferative diseases
- Patent Title (中): 使用影响细胞周期控制或细胞周期进程的真核基因来诊断和治疗增殖性疾病
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Application No.: US10572289Application Date: 2004-09-15
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Publication No.: US07648827B2Publication Date: 2010-01-19
- Inventor: Christophe Echeverri , Anthony Hyman , Pierre Gönczy , Birte Sönnichsen , Steven Jones , Andrew Walsh , Liisa Koski
- Applicant: Christophe Echeverri , Anthony Hyman , Pierre Gönczy , Birte Sönnichsen , Steven Jones , Andrew Walsh , Liisa Koski
- Applicant Address: DE Dresden
- Assignee: Cenix BioScience GmbH
- Current Assignee: Cenix BioScience GmbH
- Current Assignee Address: DE Dresden
- Agency: Connolly Bove Lodge & Hutz LLP
- International Application: PCT/EP2004/010308 WO 20040915
- International Announcement: WO2005/025624 WO 20050324
- Main IPC: G01N33/574
- IPC: G01N33/574
Abstract:
The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti-proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.
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