Invention Grant
US07648963B2 Molecules of the PYRIN/NBS/LRR protein family and uses thereof
失效
PYRIN / NBS / LRR蛋白家族的分子及其用途
- Patent Title: Molecules of the PYRIN/NBS/LRR protein family and uses thereof
- Patent Title (中): PYRIN / NBS / LRR蛋白家族的分子及其用途
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Application No.: US11346858Application Date: 2006-02-01
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Publication No.: US07648963B2Publication Date: 2010-01-19
- Inventor: John Bertin , Weiye Wang , Maria Blatcher
- Applicant: John Bertin , Weiye Wang , Maria Blatcher
- Applicant Address: US MA Cambridge US NJ Madison
- Assignee: Millennium Pharmaceuticals, Inc.,Wyeth
- Current Assignee: Millennium Pharmaceuticals, Inc.,Wyeth
- Current Assignee Address: US MA Cambridge US NJ Madison
- Agency: Fish & Richardson P.C.
- Main IPC: C07H21/02
- IPC: C07H21/02
Abstract:
Novel PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 proteins, the invention further provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 fusion proteins, antigenic peptides and anti-PYRIN-2, -PYRIN-3, -PYRIN-5, -PYRIN-6, -PYRIN-7, -PYRIN-8, -PYRIN-10, and -PYRIN-11 antibodies. The invention also provides PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, and PYRIN-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a PYRIN-2, PYRIN-3, PYRIN-5, PYRIN-6, PYRIN-7, PYRIN-8, PYRIN-10, or PYRIN-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
Public/Granted literature
- US20060270593A1 Novel molecules of the PYRIN/NBS/LRR protein family and uses thereof Public/Granted day:2006-11-30
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