Invention Grant
- Patent Title: Substituted benzylaminoalkylene heterocycles
- Patent Title (中): 取代的苄基氨基亚烷基杂环
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Application No.: US10575627Application Date: 2004-10-05
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Publication No.: US07649005B2Publication Date: 2010-01-19
- Inventor: Patricia Salvati , Carla Caccia , Piero Melloni , Alessandra Restivo , Cibele Sabido David , Stefania Vallese
- Applicant: Patricia Salvati , Carla Caccia , Piero Melloni , Alessandra Restivo , Cibele Sabido David , Stefania Vallese
- Applicant Address: IT Bresso
- Assignee: Newron Pharmaceuticals S.p.A.
- Current Assignee: Newron Pharmaceuticals S.p.A.
- Current Assignee Address: IT Bresso
- Agency: Young & Thompson
- Priority: EP03023342 20031015
- International Application: PCT/EP2004/011104 WO 20041005
- International Announcement: WO2005/040138 WO 20050506
- Main IPC: A61K31/44
- IPC: A61K31/44 ; C07D213/02

Abstract:
This invention is related to compounds of general formula (I) wherein X is oxygen or sulphur or a NR7 group; R1 is C3-C8 alkyl, or C1-C8 alkyl substituted by phenoxy or phenyl, both phenoxy or phenyl being optionally substituted by one or more fluoro, chloro, trifluoromethyl, C1-C6 alkyl, hydroxyl, C1-C6 alkoxy; R2, R3 are independently hydrogen, C1-C6 alkyl, halogen, trifluoromethyl, hydroxy or C1-C6 alkoxy; R4 is hydrogen, C1-C8 alkyl; R5, R6 are independently hydrogen, C1-C3 alkyl, optionally substituted by hydroxy or phenyl; R7 is hydrogen or straight or branched C1-C3 alkyl; Het is a five to seven membered, saturated or unsaturated heteromonocyclic or an eight to ten membered, saturated or unsaturated heterobicyclic group, containing one or more heteroatoms chosen independently from nitrogen, oxygen and sulphur, said mono- or bicyclic groups being optionally substituted by C1-C6alkyl, halogen, hydroxyl or C1-C6 alkoxy; and the pharmaceutically acceptable salts or prodrug thereof, that are active as sodium and/or calcium channel modulators and/or as selective MAO-B inhibitors and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
Public/Granted literature
- US20070135496A1 Substituted benzylaminoalkylene heterocycles Public/Granted day:2007-06-14
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