Invention Grant
US07651997B2 Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them
失效
含脱氧脯氨酸的tamandarin和didemnin类似物，含脱氢脯氨酸的tamandarin和didemnin类似物，以及制备和使用它们的方法
- Patent Title: Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them
- Patent Title (中): 含脱氧脯氨酸的tamandarin和didemnin类似物，含脱氢脯氨酸的tamandarin和didemnin类似物，以及制备和使用它们的方法
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Application No.: US11455937Application Date: 2006-06-20
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Publication No.: US07651997B2Publication Date: 2010-01-26
- Inventor: Madeleine M. Joullie , Bo Liang , Xiaobin Ding
- Applicant: Madeleine M. Joullie , Bo Liang , Xiaobin Ding
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Sterne, Kessler, Goldstein & Fox, P.L.L.C.
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/12 ; C07K16/00
Abstract:
The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
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