Invention Grant
- Patent Title: 2′, 5′-oligoadenylate analogs
- Patent Title (中): 2',5'-寡腺苷酸类似物
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Application No.: US11131412Application Date: 2005-05-16
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Publication No.: US07651999B2Publication Date: 2010-01-26
- Inventor: Makoto Koizumi , Koji Morita
- Applicant: Makoto Koizumi , Koji Morita
- Applicant Address: JP Tokyo
- Assignee: Sankyo Company, Limited
- Current Assignee: Sankyo Company, Limited
- Current Assignee Address: JP Tokyo
- Agency: Frishauf, Holtz, Goodman & Chick, P.C.
- Priority: JP2002-334731 20021119
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/02

Abstract:
A 2-5A analog represented by the formula (1): wherein m is 0 or 1; n is 0 to 2; R1 represents an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R2, R3, R4, R5 and R6 represent an unprotected hydroxyl group, a hydroxyl group protected by a nucleic acid synthesis protecting group, an alkoxy group having from 1 to 6 carbon atoms which may be substituted, an unprotected mercapto group, a mercapto group protected by a nucleic acid synthesis protecting group, or an alkylthio group having from 1 to 4 carbon atoms which may be substituted; R7 represents an oxygen atom, or a —O(CH2CH2O)q- group, wherein q is 2 to 6; R8 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms which may be substituted, or a 5′-phosphorylated oligonucleotide analog which has one hydroxyl group removed from the 5′-phosphoric acid group; E1, E2, E3 and E4 represent a naturally occurring or modified nucleic acid unit, or a pharmacologically acceptable salt thereof.
Public/Granted literature
- US20050261235A1 2' ,5' -Oligoadenylate analogs Public/Granted day:2005-11-24
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