Invention Grant
- Patent Title: Tricyclic benzopyran compound as anti-arrhythmic agents
- Patent Title (中): 三环苯并吡喃化合物作为抗心律不齐药
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Application No.: US10590975Application Date: 2005-03-23
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Publication No.: US07652008B2Publication Date: 2010-01-26
- Inventor: Kazuhiko Ohrai , Yukohiro Shigeta , Osamu Uesugi , Takumi Okada , Tomoyuki Matsuda
- Applicant: Kazuhiko Ohrai , Yukohiro Shigeta , Osamu Uesugi , Takumi Okada , Tomoyuki Matsuda
- Applicant Address: JP Tokyo
- Assignee: Nissan Chemical Industries, Ltd.
- Current Assignee: Nissan Chemical Industries, Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Oliff & Berridge, PLC
- Priority: JP2004-084605 20040323
- International Application: PCT/JP2005/006004 WO 20050323
- International Announcement: WO2005/090357 WO 20050929
- Main IPC: A61K31/436
- IPC: A61K31/436 ; A61K31/519 ; A61K31/4365 ; C07D265/38 ; C07D491/06 ; C07D498/06

Abstract:
This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.
Public/Granted literature
- US20080004262A1 Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents Public/Granted day:2008-01-03
Information query
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