Invention Grant
US07652014B2 Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
有权
取代的6-环己基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（ADP-核糖）聚合酶抑制剂
- Patent Title: Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
- Patent Title (中): 取代的6-环己基烷基取代的2-喹啉酮和2-喹喔啉酮作为聚（ADP-核糖）聚合酶抑制剂
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Application No.: US10596083Application Date: 2004-11-18
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Publication No.: US07652014B2Publication Date: 2010-01-26
- Inventor: Dominique Jean-Pierre Mabire , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
- Applicant: Dominique Jean-Pierre Mabire , Jacobus Alphonsus Josephus Van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica
- Current Assignee: Janssen Pharmaceutica
- Current Assignee Address: BE Beerse
- Priority: EP03078918 20031210
- International Application: PCT/EP2004/013165 WO 20041118
- International Announcement: WO2005/058843 WO 20050630
- Main IPC: A61K31/472
- IPC: A61K31/472 ; A61K31/498 ; A61K31/4709 ; C07D241/44 ; C07D215/227 ; C07D401/06
Abstract:
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, s, R1, R2, R3, Q, X and Y have defined meanings.
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