Invention Grant
US07652024B2 Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
失效
酰基化螺哌啶衍生物作为黑皮质素-4受体调节剂
- Patent Title: Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
- Patent Title (中): 酰基化螺哌啶衍生物作为黑皮质素-4受体调节剂
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Application No.: US12083567Application Date: 2006-10-13
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Publication No.: US07652024B2Publication Date: 2010-01-26
- Inventor: Raman K. Bakshi , James P. Dellureficio , Peter H. Dobbelaar , Liangqin Guo , Shuwen He , Qingmei Hong , Ravi P. Nargund , Zhixiong Ye
- Applicant: Raman K. Bakshi , James P. Dellureficio , Peter H. Dobbelaar , Liangqin Guo , Shuwen He , Qingmei Hong , Ravi P. Nargund , Zhixiong Ye
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Richard C. Billups; Catherine D. Fitch
- International Application: PCT/US2006/040198 WO 20061013
- International Announcement: WO2007/047496 WO 20070426
- Main IPC: A61K31/438
- IPC: A61K31/438 ; C07D491/107
Abstract:
Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.
Public/Granted literature
- US20090325990A1 ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS Public/Granted day:2009-12-31
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