Invention Grant
- Patent Title: Method of preparing clopidogrel and intermediates used therein
- Patent Title (中): 制备氯吡格雷的方法及其中使用的中间体
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Application No.: US11917794Application Date: 2005-11-28
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Publication No.: US07652140B2Publication Date: 2010-01-26
- Inventor: Eun Sook Kim , Hee Cheol Kim , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
- Applicant: Eun Sook Kim , Hee Cheol Kim , Bo Sung Kwon , Sangmin Yun , Mi Young Ko , Cheol Kyung Kim , Kwee Hyun Suh
- Applicant Address: KR Kyungki-do
- Assignee: Hanmi Pharm. Co., Ltd
- Current Assignee: Hanmi Pharm. Co., Ltd
- Current Assignee Address: KR Kyungki-do
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2005-0054303 20050623
- International Application: PCT/KR2005/004017 WO 20051128
- International Announcement: WO2006/137628 WO 20061228
- Main IPC: C07D495/04
- IPC: C07D495/04
Abstract:
Optically pure clopidogrel can be prepared in a high yield by optically resolving a racemic form of the compound of formula (II) using an optically active amine to form the optically active form of the compound of formula (III) or its acid-addition salt; and methylating the compound of formula (III) or its acid-addition salt.
Public/Granted literature
- US20080214821A1 Method of Preparing Clopidogrel and Intermediates Used Therein Public/Granted day:2008-09-04
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