Invention Grant
- Patent Title: Process for preparation of Irbesartan
- Patent Title (中): 厄贝沙坦制备方法
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Application No.: US11406919Application Date: 2006-04-19
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Publication No.: US07652147B2Publication Date: 2010-01-26
- Inventor: Pandurang Balwant Deshpande , Parven Kumar Luthra , Dhiraj Mohansinh Rathod , Hitesh Kantilal Patel , Pinky Tarak Parikh
- Applicant: Pandurang Balwant Deshpande , Parven Kumar Luthra , Dhiraj Mohansinh Rathod , Hitesh Kantilal Patel , Pinky Tarak Parikh
- Applicant Address: IN Vadodara, Gujarat
- Assignee: Alembic Limited
- Current Assignee: Alembic Limited
- Current Assignee Address: IN Vadodara, Gujarat
- Agency: Volpe and Koenig, P.C.
- Priority: IN1360/MUM/2005 20051028
- Main IPC: C07D257/00
- IPC: C07D257/00 ; C07D403/00

Abstract:
A process for the preparation of Irbesartan of formula (I) using the steps of: (i) reacting 4′ aminomethyl-2-cyano biphenyl of formula (VI) with 1-veleramido cyclopentane carboxylic acid of formula (V) in an organic solvent and in the presence of an acid, without activating the —COOH group of compound of formula (V) to give 1-(2′cyanobiphenyl-4-yl-methylaminocarbonyl)-1-pentanoylamino cyclopentane of formula (VII). converting the compound of formula (VII) obtained in step (i) to Irbesartan of formula (I) by reacting the compound of the formula (VII) with tributyl tin azide in o-xylene to give Irbesartan of formula (I).
Public/Granted literature
- US20070099973A1 Process for preparation of Irbesartan Public/Granted day:2007-05-03
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