Invention Grant
- Patent Title: Synthetic method of optically pure (S)-3-hydroxypyrrolidine
- Patent Title (中): 光学纯(S)-3-羟基吡咯烷的合成方法
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Application No.: US11996011Application Date: 2006-07-19
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Publication No.: US07652152B2Publication Date: 2010-01-26
- Inventor: Kyoung Rok Roh , Ji Sang Yoo , Jong Won Jang , Dae Yon Lee
- Applicant: Kyoung Rok Roh , Ji Sang Yoo , Jong Won Jang , Dae Yon Lee
- Applicant Address: KR Daejeon
- Assignee: Chiroad Incorporate
- Current Assignee: Chiroad Incorporate
- Current Assignee Address: KR Daejeon
- Agency: Frommer Lawrence & Haug LLP
- Agent Ronald R. Santucci
- Priority: KR10-2005-0065698 20050720
- International Application: PCT/KR2006/002835 WO 20060719
- International Announcement: WO2007/011162 WO 20070125
- Main IPC: C07D207/12
- IPC: C07D207/12

Abstract:
A method of preparing optically pure (S)-3-hydroxypyrrolidine is disclosed. The present invention provides a method of economically and industrially preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising introducing an amine protecting group by using optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, reducing a carboxylic acid group into a primary alcohol, removing the amine protecting group to form an amine salt, halogenating the primary alcohol, and amine cyclization; and through a simple purification process, i.e., distillation under reduced pressure. As another method, the present invention provides a method of preparing optically and chemically pure (S)-3-hydroxypyrrolidine, through a process comprising esterifying optically pure 4-amino-(S)-2-hydroxybutylic acid as a starting material, lactam cyclization, and reduction.
Public/Granted literature
- US20080214837A1 Synthetic Method of Optically Pure (S)-3-Hydroxypyrrolidine Public/Granted day:2008-09-04
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