Invention Grant
![(2R)-2-[(4-sulfonyl) aminophenyl] propanamides and pharmaceutical compositions containing them](/docs/US/2010-01-26/US07652169B2/abs.jpg.600x600.jpg)
- Patent Title: (2R)-2-[(4-sulfonyl) aminophenyl] propanamides and pharmaceutical compositions containing them
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Application No.: US12227519Application Date: 2007-05-17
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Publication No.: US07652169B2Publication Date: 2010-01-26
- Inventor: Marcello Allegretti , Riccardo Bertini , Cinzia Bizzarri , Maria Candida Cesta , Andrea Aramini , Alessio Moriconi
- Applicant: Marcello Allegretti , Riccardo Bertini , Cinzia Bizzarri , Maria Candida Cesta , Andrea Aramini , Alessio Moriconi
- Applicant Address: IT L'Aquila
- Assignee: Dompe' Pha. R. Ma S.p.A.
- Current Assignee: Dompe' Pha. R. Ma S.p.A.
- Current Assignee Address: IT L'Aquila
- Agency: Abelman, Frayne & Schwab
- Priority: EP06114185 20060518
- International Application: PCT/EP2007/054806 WO 20070517
- International Announcement: WO2007/135080 WO 20071129
- Main IPC: C07C303/00
- IPC: C07C303/00 ; A01N41/06
![(2R)-2-[(4-sulfonyl) aminophenyl] propanamides and pharmaceutical compositions containing them](/abs-image/US/2010/01/26/US07652169B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to novel (2R)-2-phenylpropanamides bearing a 4-sulfonylamino substituent on the 4 position of the phenyl group and to pharmaceutical compositions containing them, which are used as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells, and which are useful in the treatment of various ELR+CXC chemokine-mediated disorders. In particular, the compounds of the invention are useful in the treatment and control of specific CXCR2 dependent pathologies such as BOS, COPD, angiogenesis and melanoma.
Public/Granted literature
- US20090093530A1 (2R)-2-[4-Sulfonyl) Aminophenyl] Propanamides and Pharmaceutical Compositions Containing Them Public/Granted day:2009-04-09
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