A Refillable dental flosser dispenser stores and sequentially dispenses a plurality of dental flossers each of which flossers has first and second sides and an edge extending between the first and second sides. The dispenser includes a housing having a refill end, a dispensing end and a housing side wall extending between the refill and dispensing ends. The housing side wall defines an internal storage cavity within which plural flossers are stored in a side-by-side serial arrangement. A dispensing-end wall combines with a housing side wall to define a side-emitting dispensing slot dimensioned so as to permit the edgewise withdrawal from within the storage cavity of only a single flosser at a time. Flossers within the storage cavity are positionally biased toward the dispensing wall for edgewise alignment with the dispensing slot such that, as each successive flosser is extracted from the storage cavity through the dispensing slot, each remaining flosser is incrementally advanced toward the dispensing-end wall by a distance corresponding to a single flosser width. A replaceable refill cartridge capable of containing plural flossers includes an open end through which flossers are sequentially fed into edgewise alignment with the dispensing slot.