The present invention provides a device for efficiently coupling a pressure monitoring device to a pressure transducer. In addition, the present invention reduces or eliminates the likelihood air will be unintentionally injected into the pressure monitoring device while connecting the pressure monitoring device to a pressure transducer. In one embodiment, the present invention includes a pressure monitoring coupler comprising a sealing member and a device body. The sealing member comprises a sealing flange connected to an engagement member. The engagement member includes a first and second O-ring positioned thereon. The device body comprises a pressurizing lumen and an intersecting monitoring lumen in communication with a receiving aperture. During use, a pressure monitoring catheter is inserted into a patient's tissue. The pressure monitoring catheter and a transducer are connected to the device body of the present invention. Thereafter, the sealing member is inserted into the device body while the pressure within the pressure monitoring catheter is maintained at or less than a state or equilibrium with the pressure applied by the tissue.