Invention Grant
US07655233B2 Optimal placement of a robust solvent/detergent process post viral ultrafiltration of an immune gamma globulin
有权
在免疫γ球蛋白的病毒超滤之后优化放置坚固的溶剂/洗涤剂过程
- Patent Title: Optimal placement of a robust solvent/detergent process post viral ultrafiltration of an immune gamma globulin
- Patent Title (中): 在免疫γ球蛋白的病毒超滤之后优化放置坚固的溶剂/洗涤剂过程
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Application No.: US11274812Application Date: 2005-11-15
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Publication No.: US07655233B2Publication Date: 2010-02-02
- Inventor: Robert W. Van Holten , Stephen M. Autenrieth
- Applicant: Robert W. Van Holten , Stephen M. Autenrieth
- Applicant Address: US NY Rochester
- Assignee: Ortho-Clinical Diagnostics, Inc.
- Current Assignee: Ortho-Clinical Diagnostics, Inc.
- Current Assignee Address: US NY Rochester
- Main IPC: A61K39/00
- IPC: A61K39/00
Abstract:
The solvent-detergent (S/D) process is used to inactivate enveloped viruses in plasma products. While concentrations of 1.0% detergent and 0.3% tri-n-butyl phosphate solvent have been considered necessary for robust removal of viral activity, we show the effectiveness of solvent-detergent treatment after fractionation and nanofiltration of an immune gamma globulin preparation, which required significantly reduced concentrations of solvent and detergent. Reduced levels of solvent and detergent lead to greater efficiencies in their removal post-inactivation with the potential for greater yields and decreased processing costs.
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