Invention Grant
- Patent Title: Compositions and methods for detection and treatment of proliferative abnormalities associated with overexpression of human transketolase like-1 gene
- Patent Title (中): 用于检测和治疗与人类转酮酶样-1基因过表达相关的增殖异常的组合物和方法
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Application No.: US10511813Application Date: 2003-04-12
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Publication No.: US07655398B2Publication Date: 2010-02-02
- Inventor: Johannes Coy
- Applicant: Johannes Coy
- Agency: Patent Central LLC
- Agent Stephan A. Pendorf
- Priority: EP02008831 20020419
- International Application: PCT/EP03/03827 WO 20030412
- International Announcement: WO03/089667 WO 20031030
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
The present invention relates to methods for treatment and diagnosis of disorders associated with abnormally proliferating cells. In one aspect the invention relates to methods, which are especially useful for the detection of tumors and their precursory stages based on the detection of overexpression of human transketolase like-1 gene in biological samples. In another aspect the invention relates to methods for treatment of disorders associated with the overexpression of human transketolase like-1 gene. Methods for treatment may include gene therapeutic approaches as well as methods for inhibiting or reducing the activity of transketolase like-1 polypeptides.
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