Invention Grant
- Patent Title: Methods for prenatal diagnosis of chromosomal abnormalities
- Patent Title (中): 产前诊断染色体异常的方法
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Application No.: US10575119Application Date: 2004-10-08
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Publication No.: US07655399B2Publication Date: 2010-02-02
- Inventor: Charles R Cantor , Chunming Ding
- Applicant: Charles R Cantor , Chunming Ding
- Applicant Address: US MA Boston
- Assignee: Trustees of Boston University
- Current Assignee: Trustees of Boston University
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- International Application: PCT/US2004/033175 WO 20041008
- International Announcement: WO2005/035725 WO 20050421
- Main IPC: C12Q1/68
- IPC: C12Q1/68

Abstract:
Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention exploits the differences in DNA between the mother and fetus, for instance differences in their methylation states, as a means to enrich for fetal DNA in maternal plasma sample. The methods described herein can be used to detect chromosomal DNA deletions and duplications. In a preferred embodiment, the methods are used to diagnose chromosomal aneuploidy and related disorders, such as Down's and Turner's Syndrome.
Public/Granted literature
- US20070059707A1 Methods for prenatal diagnosis of chromosomal abnormalities Public/Granted day:2007-03-15
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