Invention Grant
US07655408B2 PCA3 messenger RNA species in benign and malignant prostate tissues
有权
PCA3信使RNA物种在良性和恶性前列腺组织中
- Patent Title: PCA3 messenger RNA species in benign and malignant prostate tissues
- Patent Title (中): PCA3信使RNA物种在良性和恶性前列腺组织中
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Application No.: US12098577Application Date: 2008-04-07
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Publication No.: US07655408B2Publication Date: 2010-02-02
- Inventor: Ursula Busse , Camille Chypre , Yves Fradet
- Applicant: Ursula Busse , Camille Chypre , Yves Fradet
- Applicant Address: CA Ste-Foy
- Assignee: Diagnocure Inc.
- Current Assignee: Diagnocure Inc.
- Current Assignee Address: CA Ste-Foy
- Agency: Goudreau Gage Dubuc
- Main IPC: C12Q1/68
- IPC: C12Q1/68
Abstract:
This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer whereas the long RNA sequence is associated with a non-malignant state of the prostate. Based on the differential expression levels of these two PCA3 RNA sequences, protocols for the diagnosis of prostate disease are provided. The invention also relates to therapeutic approaches to prostate cancer.
Public/Granted literature
- US20080261228A1 PCA3 Messenger RNA Species in Benign and Malignant Prostate Tissues Public/Granted day:2008-10-23
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