Invention Grant
US07655446B2 Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof
有权
Rho激酶I激酶结构域复合物的晶体结构及其结合位点
- Patent Title: Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof
- Patent Title (中): Rho激酶I激酶结构域复合物的晶体结构及其结合位点
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Application No.: US11478194Application Date: 2006-06-28
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Publication No.: US07655446B2Publication Date: 2010-02-02
- Inventor: Marc Jacobs , Koto Hayakawa , Mark Fleming , John Doran , Craig Marhefka
- Applicant: Marc Jacobs , Koto Hayakawa , Mark Fleming , John Doran , Craig Marhefka
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Ropes & Gray LLP
- Agent James F. Haley, Jr.; Raymond M. Doss
- Main IPC: C12N9/00
- IPC: C12N9/00 ; G01N31/00
Abstract:
The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to ROCK I protein or ROCK I protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising ROCK I kinase domain and ROCK I kinase domain complexed with an inhibitor of that domain. The invention also relates to methods of identifying inhibitors of the ROCK I kinase domain.
Public/Granted literature
- US20090036654A1 Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof Public/Granted day:2009-02-05
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