Invention Grant
- Patent Title: Compositions and methods for systemic nucleic acid sequence delivery
- Patent Title (中): 全身核酸序列递送的组合物和方法
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Application No.: US10988723Application Date: 2004-11-15
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Publication No.: US07655467B2Publication Date: 2010-02-02
- Inventor: Jeffrey S. Chamberlain , Paul Gregorevic , Michael J. Blankinship , James M. Allen
- Applicant: Jeffrey S. Chamberlain , Paul Gregorevic , Michael J. Blankinship , James M. Allen
- Applicant Address: US WA Seattle
- Assignee: The University of Washington
- Current Assignee: The University of Washington
- Current Assignee Address: US WA Seattle
- Agency: Casimir Jones, S.C.
- Main IPC: C12N15/86
- IPC: C12N15/86 ; A61K48/00 ; A61K31/70
Abstract:
The present invention provides systemic nucleic acid sequence delivery without conventional systemic administration aids (SAAs). In certain embodiments, vascular permeability agents (VPAs), such as VEGF, are used in conjunction with nucleic acid viral vectors, such as adeno-associated virus (AAV). The present invention also provides methods of treating disease by co-administration of nucleic cid sequences encoding Igf-1 and dystrophin or dystrophin-like proteins.
Public/Granted literature
- US20050158281A1 Compositions and methods for systemic nucleic acid sequence delivery Public/Granted day:2005-07-21
Information query
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