Invention Grant
- Patent Title: Insulin-associated peptides with effects on cerebral health
- Patent Title (中): 与脑健康有关的胰岛素相关肽
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Application No.: US10430545Application Date: 2003-05-06
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Publication No.: US07655619B2Publication Date: 2010-02-02
- Inventor: Matthew J. During , Colin N. Haile
- Applicant: Matthew J. During , Colin N. Haile
- Applicant Address: US PA Philadelphia
- Assignee: Thomas Jefferson University
- Current Assignee: Thomas Jefferson University
- Current Assignee Address: US PA Philadelphia
- Agency: Nutter McClennen & Fish LLP
- Agent Thomas J. Engellenner
- Main IPC: A61K38/28
- IPC: A61K38/28 ; A61K38/12
Abstract:
The present invention provides compositions and methods for ameliorating neurological, attention, or memory disorders and improving learning and cognition through the delivery of insulin A-chain and analogs thereof to a subject. Insulin A-chain, peptides comprising the 21 amino acid sequence GIVEQ CCASV CSLYQ LENYC N (SEQ ID NO:1), and functional analogs thereof are disclosed to modulate neurological activity when administered to a subject. The methods of the invention can be used to prevent or treat neurological disorders as well as improve memory retention and acquisition. The invention includes pharmaceutical compositions comprising a therapeutically or prophylactically effective amount of insulin A-chain peptide or a functional analogs thereof.
Public/Granted literature
- US20040014660A1 Insulin-associated peptides with effects on cerebral health Public/Granted day:2004-01-22
Information query
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