Invention Grant
US07655624B2 Peptide and peptide mimetic conjugates with integrin-inhibitor properties
有权
具有整合素抑制剂性质的肽和肽模拟物缀合物
- Patent Title: Peptide and peptide mimetic conjugates with integrin-inhibitor properties
- Patent Title (中): 具有整合素抑制剂性质的肽和肽模拟物缀合物
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Application No.: US10344669Application Date: 2001-08-02
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Publication No.: US07655624B2Publication Date: 2010-02-02
- Inventor: Joerg Meyer , Berthold Nies , Michel Dard , Guenter Hoelzemann , Horst Kessler , Martin Kantlehner , Ulrich Hersel , Christoph Gibson , Gabor Sulyok
- Applicant: Joerg Meyer , Berthold Nies , Michel Dard , Guenter Hoelzemann , Horst Kessler , Martin Kantlehner , Ulrich Hersel , Christoph Gibson , Gabor Sulyok
- Applicant Address: DE Berlin
- Assignee: Biomet Deutschland GmbH
- Current Assignee: Biomet Deutschland GmbH
- Current Assignee Address: DE Berlin
- Agency: Millen, White, Zelano, Branigan, P.C.
- Priority: DE10040105 20000817
- International Application: PCT/EP01/08932 WO 20010802
- International Announcement: WO02/13872 WO 20020221
- Main IPC: A61K38/12
- IPC: A61K38/12 ; A61F2/02

Abstract:
The invention relates to compounds of formula (1) B-Q-X1, wherein B is bioactive cell adhesive mediating molecule. Q is absent or is an inorganic spacer molecule and X1 is an anchor molecule, selected from the group Lys-(CO—CH2—(CH2)n—PO3H2)2(I), -Lys-[-Lys-(CO—CH2—(CH2)a—PO3H2)2]2(ii) or -Lys-(Lys[-Lys-(CO—CH2—(CH2)n—PO3H2]2 (iii), and n independently represents 0, 1, 2 or 3, wherein a free amino group of group B is linked in peptide form to a free carboxyl group of the spacer molecule Q or of the anchor molecule X1, or a free amino group of the radical Q is linked in peptide form to a free carboxyl group of the radical X1. The invention also relates to the salts thereof. The inventive compounds can be used as integrin inhibitors for the treatment of illnesses, deficiencies, inflammations caused by implants and osteolytic illnesses such as osteoporosis, thrombosis, cardiac infarction and arteriosclerosis, in addition to the acceleration and strengthening of the integration process of implants or the biocompatible surface in tissue.
Public/Granted literature
- US20040029782A1 Peptide and peptide mimetic conjugates with integrin-inhibitor properties Public/Granted day:2004-02-12
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