Invention Grant
- Patent Title: N-pyrazole A2A receptor agonists
- Patent Title (中): N-吡唑A2A受体激动剂
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Application No.: US11588834Application Date: 2006-10-27
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Publication No.: US07655637B2Publication Date: 2010-02-02
- Inventor: Jeff A. Zablocki , Elfatih O. Elzein , Venkata Palle , Luiz Belardinelli
- Applicant: Jeff A. Zablocki , Elfatih O. Elzein , Venkata Palle , Luiz Belardinelli
- Applicant Address: US CA Foster City
- Assignee: Gilead Palo Alto, Inc.
- Current Assignee: Gilead Palo Alto, Inc.
- Current Assignee Address: US CA Foster City
- Agency: Swiss Tanner, P.C.
- Main IPC: A61K31/70
- IPC: A61K31/70
Abstract:
2-adenosine N-pyrazole compounds having the following formula: wherein R1═CH2OH; R2 is hydrogen; R3 is selected from the group consisting of CO2R20; —CONR7R8 ,and aryl wherein the aryl substituent is optionally substituted with one substituent selected from the group consisting of halo, C 1-3alkyl and OR20;R4 is hydrogen; R7 is selected from hydrogen, and C1-3alkyl; R8 is hydrogen; and R20 is selected from hydrogen and methyl as well as methods for using the compositions as A2A receptor agonists to stimulate mammalian coronary vasodilatation for therapeutic purposes and for purposes of imaging the heart are disclosed.
Public/Granted literature
- US20070203090A1 N-pyrazole A2A receptor agonists Public/Granted day:2007-08-30
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