Invention Grant
- Patent Title: Piperidine and azetidine derivatives as GlyT1 inhibitors
- Patent Title (中): 哌啶和氮杂环丁烷衍生物作为GlyT1抑制剂
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Application No.: US11792111Application Date: 2005-12-21
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Publication No.: US07655644B2Publication Date: 2010-02-02
- Inventor: Wesley Peter Blackaby , Stephen Robert Fletcher , Andrew Jennings , Richard Thomas Lewis , Elizabeth Mary Naylor , Leslie Joseph Street , Joanne Thomson
- Applicant: Wesley Peter Blackaby , Stephen Robert Fletcher , Andrew Jennings , Richard Thomas Lewis , Elizabeth Mary Naylor , Leslie Joseph Street , Joanne Thomson
- Applicant Address: GB Hoddesdon
- Assignee: Merck Sharp & Dohme Limited
- Current Assignee: Merck Sharp & Dohme Limited
- Current Assignee Address: GB Hoddesdon
- Agent William Krovatin; Raynard Yuro
- Priority: GB0427987.3 20041221; GB0427989.9 20041221
- International Application: PCT/GB2005/050258 WO 20051221
- International Announcement: WO2006/067529 WO 20060629
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/454 ; A61K31/4545

Abstract:
The present invention provides compounds of formula (I), wherein both p's are one or two, R1 is generally heteroaryl or cycloalkyl, R2 is C3-6cycloalkyl or phenyl and R3 is heteroaryl, and pharmaceutically acceptable salts thereof, as GlyT1 inhibitors for treating schizophrenia, pharmaceutical compositions comprising the same and methods for their preparation.
Public/Granted literature
- US20080090796A1 Piperidine And Azetidine Derivatives As Glyt1 Inhibitors Public/Granted day:2008-04-17
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