Invention Grant
- Patent Title: Substituted lactams as inhibitors of Aβ protein production
- Patent Title (中): 取代的内酰胺作为Abeta蛋白质生产的抑制剂
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Application No.: US12388944Application Date: 2009-02-19
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Publication No.: US07655647B2Publication Date: 2010-02-02
- Inventor: Qi Han , Hong Liu , Richard E. Olson , Michael G. Yang
- Applicant: Qi Han , Hong Liu , Richard E. Olson , Michael G. Yang
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Pharma Company
- Current Assignee: Bristol-Myers Squibb Pharma Company
- Current Assignee Address: US NJ Princeton
- Agency: Kelley Drye & Warren LLP
- Agent Pamela A. Mingo
- Main IPC: A61K31/55
- IPC: A61K31/55 ; C07D243/12 ; A61P25/28
Abstract:
This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
Public/Granted literature
- US20090170831A1 SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION Public/Granted day:2009-07-02
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