Invention Grant
- Patent Title: Crystallized structure of estrogen related receptor gamma in complex with bisphenol A
- Patent Title (中): 与双酚A复合的雌激素相关受体γ结晶结构
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Application No.: US11442004Application Date: 2006-05-26
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Publication No.: US07655756B2Publication Date: 2010-02-02
- Inventor: Marta C. Abad , Dionisios Rentzeperis , John O'Neill , Hossein B. Askari , Cynthia M. Milligan , Frank A. Lewandowski
- Applicant: Marta C. Abad , Dionisios Rentzeperis , John O'Neill , Hossein B. Askari , Cynthia M. Milligan , Frank A. Lewandowski
- Applicant Address: US NJ New Brunswick
- Assignee: Johnson & Johnson Pharmaceutical Research & Development, LLC
- Current Assignee: Johnson & Johnson Pharmaceutical Research & Development, LLC
- Current Assignee Address: US NJ New Brunswick
- Agent Andrea Jo Kamage
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K38/16 ; C08H1/00
Abstract:
A method for the identification of novel compounds that interact and stabilize the ligand binding domain of estrogen-related receptor gamma (ERRγ), a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands, including Bisphenol A, and the identification of novel biologically-active compounds that have an effect on the transcriptional-activating activity of ERRγ are disclosed.
Public/Granted literature
- US20060270836A1 EERgamma peptide fragment complexes and uses thereof in drug discovery Public/Granted day:2006-11-30
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