Invention Grant
- Patent Title: Cytotoxic ribonuclease variants
- Patent Title (中): 细胞毒性核糖核酸酶变体
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Application No.: US11454418Application Date: 2006-06-16
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Publication No.: US07655757B2Publication Date: 2010-02-02
- Inventor: Ronald T. Raines , George N. Phillips, Jr. , R. Jeremy Johnson , Jason G. McCoy
- Applicant: Ronald T. Raines , George N. Phillips, Jr. , R. Jeremy Johnson , Jason G. McCoy
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Quarles & Brady LLP
- Main IPC: C07K14/00
- IPC: C07K14/00 ; C08H1/00 ; A61K39/00
Abstract:
This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase 1 hRI complex. Also disclosed is the 3-D structure of the hRI.RNase 1 complex and methods for designing the RNase 1 variants.
Public/Granted literature
- US20060292137A1 Cytotoxic ribonuclease variants Public/Granted day:2006-12-28
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