Invention Grant
- Patent Title: Stable liquid IL-1 antagonist formulations
- Patent Title (中): 稳定的液体IL-1拮抗剂制剂
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Application No.: US12048717Application Date: 2008-03-14
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Publication No.: US07655758B2Publication Date: 2010-02-02
- Inventor: Daniel Dix , Katherine Bowers , Chimanlall Goolcharran , Leu-Fen H. Lin
- Applicant: Daniel Dix , Katherine Bowers , Chimanlall Goolcharran , Leu-Fen H. Lin
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agent Valeta Gregg, Esq.; Tor Smeland, Esq.
- Main IPC: A61K36/20
- IPC: A61K36/20 ; A61K47/48 ; C07K14/475
Abstract:
Formulations of an interleukin-1 (IL-1) antagonist are provided including a pre-lyophilized formulation, a reconstituted lyophilized formulation, and a stable liquid formulation. Preferably, the IL-1 antagonist is an IL-1 trap composed of a dimer of two fusion proteins having an amino acid sequence of SEQ ID NO: 10. Stable liquid formulations made with and without sodium chloride, and made with phosphate or histidine buffer, are provided.
Public/Granted literature
- US20080188817A1 Stable Liquid IL-1 Antagonist Formulations Public/Granted day:2008-08-07
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