Invention Grant
US07655804B2 Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient
失效
二酮肼衍生物化合物和含有这些化合物作为活性成分的药物
- Patent Title: Diketohydrazine derivative compounds and drugs containing the compounds as the active ingredient
- Patent Title (中): 二酮肼衍生物化合物和含有这些化合物作为活性成分的药物
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Application No.: US10512348Application Date: 2003-04-24
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Publication No.: US07655804B2Publication Date: 2010-02-02
- Inventor: Akira Hatayama , Hiroshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
- Applicant: Akira Hatayama , Hiroshi Tsuruta , Yasuo Ochi , Haruo Imawaka , Kazuyuki Ohmoto
- Applicant Address: JP Osaka
- Assignee: Ono Pharmaceutical Co., Ltd.
- Current Assignee: Ono Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: JP2002-123796 20020425
- International Application: PCT/JP03/05252 WO 20030424
- International Announcement: WO03/091202 WO 20031106
- Main IPC: C07D417/12
- IPC: C07D417/12
Abstract:
The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula (I) has an inhibitory activity against cysteine protease, and it is useful for the treatment of inflammatory diseases, immune diseases, ischemic diseases, respiratory diseases, circulatory diseases, blood diseases, neuronal diseases, hepatic or biliary diseases, osseous or articular diseases, metabolic diseases, etc. And the compound has inhibitory activity against elastase and it is also useful for the treatment of COPD (chronic obstacle pulmonary diseases).
Public/Granted literature
- US20060111303A1 Diketohydrazine derivative compounds and drugs contaiing the compounds as the active ingredient Public/Granted day:2006-05-25
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