A mobile portal for RFID applications includes an RFID reader for reading identifications of proximately located RFID tagged items and a communicator for communicating with a central computer. The communicator is coupled to the RFID reader to receive the read identifications and then communicate the received read identifications over a wireless interface to a central data processing system. Each mobile portal may be actuated for RFID read operations in response to information sensed concerning operation of the mobile asset/vehicle. Additionally, the central data processing system may issue instructions concerning mobile asset/vehicle operation, with those instructions communicated over the wireless interface to the mobile portal. Responsive to implementation of those instructions, the mobile portal actuates the RFID reader and compares the read identifications to a list of RFID tags that were expected to be read.