A method and system for reducing interference in a wireless communication network is disclosed. The wireless communication network has at least one base station using an antenna array and one or more code channels to receive or transmit one or more communication signals from or to a plurality of terminals used by one or more users. A signal received by the antenna array carries one or more training sequences and a traffic signal in a frame. After estimating a spatial signature and joint channel response model per user based on the training sequences, one or more spatial weights are found based on the estimated spatial signature and joint channel response model to maximize a signal to noise ratio. A joint detection matrix is then formed based on the estimated spatial weights, the joint channel response model, and a user code channel assignment. After code correlating a traffic signal to obtain one or more user specific multi-antenna signals, a spatial combining is performed on one or more multi-antenna signals associated with each user to generate scalar symbol estimates. Thereafter, a joint detection is done based on the scalar symbol estimates using the joint detection matrix. Similar techniques can be used for downlink communications.