Invention Grant
US07657380B2 Methods of generating variant antibodies with increased host string content
有权
产生具有增加的宿主串含量的变体抗体的方法
- Patent Title: Methods of generating variant antibodies with increased host string content
- Patent Title (中): 产生具有增加的宿主串含量的变体抗体的方法
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Application No.: US11004590Application Date: 2004-12-03
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Publication No.: US07657380B2Publication Date: 2010-02-02
- Inventor: Gregory Alan Lazar , John R. Desjarlais , Philip W. Hammond
- Applicant: Gregory Alan Lazar , John R. Desjarlais , Philip W. Hammond
- Applicant Address: US CA Monrovia
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Monrovia
- Agency: Morgan Lewis & Bockius LLP
- Agent Robin M. Silva, Esq.; David C. Foster, Esq.
- Main IPC: G01N33/48
- IPC: G01N33/48 ; C12Q1/68 ; C12P21/08
Abstract:
The present invention relates to novel methods for generating variant proteins with increased host string content by comparing a parent protein sequence with two or more natural protein sequences from a host species, analyzing one or more amino acid strings of the parent protein sequence with a structurally corresponding amino acid string of each of said natural protein sequences, substituting one or more amino acid strings of the parent protein sequence with a structurally corresponding amino acid string of one of the two or more natural protein sequences on an amino acid string by amino acid string basis so that the variant protein has increased host string content, and, synthesizing and screening the variant protein.
Public/Granted literature
- US20060008883A1 Methods of generating variant proteins with increased host string content and compositions thereof Public/Granted day:2006-01-12
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