Invention Grant
- Patent Title: Structure-based hepatitis C virus drug design
- Patent Title (中): 基于结构的丙型肝炎病毒药物设计
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Application No.: US10312490Application Date: 2001-07-03
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Publication No.: US07657385B2Publication Date: 2010-02-02
- Inventor: Martino Bolognesi , Guido Grandi
- Applicant: Martino Bolognesi , Guido Grandi
- Applicant Address: IT Siena
- Assignee: Novartis Vaccines and Diagnostics, S.R.L.
- Current Assignee: Novartis Vaccines and Diagnostics, S.R.L.
- Current Assignee Address: IT Siena
- Agent Mark Seka; George Renzoni
- Priority: GB0016361.8 20000703
- International Application: PCT/IB01/01450 WO 20010703
- International Announcement: WO02/02631 WO 20020110
- Main IPC: G01N31/00
- IPC: G01N31/00 ; G06F19/00 ; A61K39/12 ; C12N7/00 ; G01N33/566
Abstract:
The extracellular loop of CD81 is a cellular receptor for the E2 protein of hepatitis C virus. A CD81 crystal structure has been elucidated and is provided for use in the structure-based design of compounds which bind to CD81 and thus block the binding of HCV. Methods such as docking and de novodrug design can be used.
Public/Granted literature
- US20030176662A1 Structure-based hepatitis c virus drug design Public/Granted day:2003-09-18
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