A system for using compatible point-of-service (POS) applications to access and control devices of a POS unit. A server runs a POS application and a set of peripheral drivers (or device controls). A networked POS unit communicates with the host server via a communication network, and the networked POS unit includes peripherals connected locally to its I/O ports. The POS unit further includes a device communications management module processing output received from the host server that is generated by the POS application and is targeted at one of the connected peripheral ports. The device communications management module transfers POS device input from the peripherals over the communication network to the host server for processing by the POS application. The POS application interfaces with the peripheral drivers, and the output is provided by one of the peripheral drivers that corresponds to the target peripheral of the networked POS unit.