Invention Grant
- Patent Title: Mutant forms of cholera holotoxin as an adjuvant
- Patent Title (中): 霍乱全毒素作为佐剂的突变形式
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Application No.: US11960226Application Date: 2007-12-19
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Publication No.: US07658931B2Publication Date: 2010-02-09
- Inventor: Bruce A. Green , Randall K. Holmes , Michael G. Jobling , Duzhang Zhu
- Applicant: Bruce A. Green , Randall K. Holmes , Michael G. Jobling , Duzhang Zhu
- Applicant Address: US NJ Madison US DC Washington
- Assignee: Wyeth Holdings Corporation,The United States of America, as represented by the Uniformed Services University of Health Sciences
- Current Assignee: Wyeth Holdings Corporation,The United States of America, as represented by the Uniformed Services University of Health Sciences
- Current Assignee Address: US NJ Madison US DC Washington
- Agency: Howson & Howson LLP
- Agent J. Darrell Fontenot
- Main IPC: C07K14/28
- IPC: C07K14/28 ; A61K39/106
Abstract:
Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.
Public/Granted literature
- US20080311144A1 MUTANT FORMS OF CHOLERA HOLOTOXIN AS AN ADJUVANT Public/Granted day:2008-12-18
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