Invention Grant
US07659062B2 Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors
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子宫浆液性乳头状癌和卵巢浆液性乳头状瘤的基因表达谱
- Patent Title: Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors
- Patent Title (中): 子宫浆液性乳头状癌和卵巢浆液性乳头状瘤的基因表达谱
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Application No.: US10859020Application Date: 2004-06-01
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Publication No.: US07659062B2Publication Date: 2010-02-09
- Inventor: Alessandro D. Santin
- Applicant: Alessandro D. Santin
- Applicant Address: US AR Little Rock
- Assignee: The Board of Trustee of the University of Arkansas System
- Current Assignee: The Board of Trustee of the University of Arkansas System
- Current Assignee Address: US AR Little Rock
- Agent Benjamin Aaron Adler
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12Q1/68
Abstract:
Oligonucleotide microarrays were used to profile and compare gene expression patterns between uterine serous papillary carcinoma and ovarian serous papillary carcinoma or normal endometrial epithelial cells. mRNA fingerprints readily distinguish the more biologically aggressive and chemotherapy resistant USPC from OSPC or NEC. Plasminogen activator inhibitor is the most highly up-regulated gene in OSPC relative to USPC, whereas the c-erbB2 gene product (HER-2/neu) is strikingly overexpressed in USPC relative to OSPC and may therefore represent a novel diagnostic and therapeutic marker for this highly aggressive subset of endometrial tumors.
Public/Granted literature
- US20050037389A1 Gene expression profiling of uterine serous papillary carcinomas and ovarian serous papillary tumors Public/Granted day:2005-02-17
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