Invention Grant
US07659106B2 Non-homogeneous systems for the resolution of enantiomeric mixtures
有权
用于解析对映异构体混合物的非均相体系
- Patent Title: Non-homogeneous systems for the resolution of enantiomeric mixtures
- Patent Title (中): 用于解析对映异构体混合物的非均相体系
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Application No.: US11318650Application Date: 2005-12-27
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Publication No.: US07659106B2Publication Date: 2010-02-09
- Inventor: Merrick R. Almond , Wang Yi Fong , Yao Yiming
- Applicant: Merrick R. Almond , Wang Yi Fong , Yao Yiming
- Applicant Address: US MA Cambridge US CA Foster City
- Assignee: Altus Pharmaceuticals Inc.,Gilead Sciences, Inc.
- Current Assignee: Altus Pharmaceuticals Inc.,Gilead Sciences, Inc.
- Current Assignee Address: US MA Cambridge US CA Foster City
- Agency: King & Spalding
- Main IPC: C12P41/00
- IPC: C12P41/00
Abstract:
The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters using a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselective synthesis of anti-viral compounds, such as 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane (FTC) and its analogues, in a non-homogenous reaction system.
Public/Granted literature
- US20070004024A1 Non-homogeneous systems for the resolution of enantiomeric mixtures Public/Granted day:2007-01-04
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