The present invention relates to a monoclonal antibody or fragment thereof, which binds specifically and/or selectively to human receptors of the Frizzled (FZD) family. It further relates to a hybridoma cell that produces the antibody according to the invention. Another object of the present invention is a method for the detection and/or isolation of receptors of the FZD family or homologs or fragments thereof in a biological sample and a method for the identification and/or isolation of biological material comprising or expressing receptors of the FZD family or homologs or fragments thereof. The invention further relates to the use of the antibody according to the invention or fragments thereof for the specific and/or selective detection and/or isolation of receptors of the FZD family, a composition comprising the monoclonal antibody according to the invention or fragments thereof, and a kit comprising the monoclonal antibody according to the invention or fragments thereof.