Invention Grant
US07659241B2 Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
有权
药物共轭物及其用于治疗癌症，自身免疫性疾病或传染病的用途
- Patent Title: Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
- Patent Title (中): 药物共轭物及其用于治疗癌症，自身免疫性疾病或传染病的用途
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Application No.: US10522911Application Date: 2003-07-31
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Publication No.: US07659241B2Publication Date: 2010-02-09
- Inventor: Peter D. Senter , Svetlana O. Doronina , Brian E. Toki
- Applicant: Peter D. Senter , Svetlana O. Doronina , Brian E. Toki
- Applicant Address: US WA Bothell
- Assignee: Seattle Genetics, Inc.
- Current Assignee: Seattle Genetics, Inc.
- Current Assignee Address: US WA Bothell
- Agency: Townsend and Townsend and Crew LLP
- International Application: PCT/US03/24209 WO 20030731
- International Announcement: WO2004/010957 WO 20040205
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K2/00
Abstract:
Compounds and compositions are disclosed in which a Drug unit (D) is linked to a Ligand unit (L). In an exemplary embodiment, the compound is of the formula LAa-Ww-Yy-D)p Ia or a pharmaceutically acceptable salt thereof, where A is a stretcher unit, W is an amino acid unit, Y is a spacer unit, D is of the formula and a, w, y, p and R2-R10 are as disclosed in the specification. Methods for treating cancer, autoimmune disease, and infectious disease using the compounds and compositions of the invention are also disclosed.
Abstract(Chinese):
公开了化合物和组合物，其中药物单元（D）与配体单元（L）连接。 在一个示例性实施方案中，该化合物具有式L Aa-Ww-Yy-D）p Ia或其药学上可接受的盐，其中A是担架单元，W是氨基 酸单元，Y是间隔单元，D具有下式：a，w，y，p和R 2 -R 10如说明书中所公开的。 还公开了使用本发明的化合物和组合物治疗癌症，自身免疫疾病和感染性疾病的方法。
Public/Granted literature
- US20060074008A1 Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease Public/Granted day:2006-04-06
Information query
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